
| 研究方向: | 海洋藥物化學(xué) |
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| 崗 位: | 副研究員 |
| 部 門: | 實(shí)驗(yàn)海洋生物學(xué)重點(diǎn)實(shí)驗(yàn)室 |
| 聯(lián)系方式: | 0532-82898741 |
| 電子郵件: | wanglijun@qdio.ac.cn |
| 個人網(wǎng)頁: |
| 理學(xué)博士,研究方向?yàn)楹Q笏幬锘瘜W(xué),主要從事海洋活性化合物的合成、結(jié)構(gòu)優(yōu)化與成藥性研究。針對腫瘤這一重大疾病,以化學(xué)小分子調(diào)控eIF4E/eIF4G和PARP1為靶點(diǎn),基于海洋來源具有顯著抗腫瘤活性化合物的優(yōu)勢骨架結(jié)構(gòu),綜合集成分子雜合、多樣性導(dǎo)向合成和計算機(jī)輔助藥物設(shè)計等技術(shù)方法,在海洋天然活性骨架上嵌入上市藥物優(yōu)勢藥效團(tuán),設(shè)計構(gòu)建結(jié)構(gòu)新穎和結(jié)構(gòu)多樣的雜合體分子組合庫,從中發(fā)現(xiàn)多個高活性靶向eIF4E/eIF4G和PARP1抑制劑,獲得1個極具開發(fā)前景的靶向eIF4E抗腫瘤苗頭化合物EGPI-1;參與兩種候選藥物開發(fā),完成一種候選藥物的全合成工藝并進(jìn)行了放大合成;在J. Med. Chem.和Eur. J. Med. Chem.等著名藥學(xué)期刊發(fā)表SCI論文50余篇,其中第一或通訊作者發(fā)表SCI論文21篇;申請專利20件,獲授權(quán)8件;主持國家自然科學(xué)基金面上項目、山東省重點(diǎn)研發(fā)計劃和中國博士后基金特別資助等6項,作為研究骨干參與國家、省部項目10余項。 |
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2009.09-2012.07,中科院昆明植物研究所,植物化學(xué)與西部植物資源持續(xù)利用國家重點(diǎn)實(shí)驗(yàn)室,博士; 2006.09-2009.06,西南大學(xué),藥學(xué)院,碩士; 1994.09-1998.07,曲阜師范大學(xué),化學(xué)與化工學(xué)院,學(xué)士; |
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2015年至今,中科院海洋研究所,實(shí)驗(yàn)海洋生物學(xué)重點(diǎn)實(shí)驗(yàn)室,副研究員; 2013.07-2015.06,中科院海洋研究所,實(shí)驗(yàn)海洋生物學(xué)重點(diǎn)實(shí)驗(yàn)室,博士后; |
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1、國家自然科學(xué)基金面上項目,基于分子雜合和多樣性導(dǎo)向合成策略構(gòu)建新型海洋溴酚雜合體庫及靶向eIF4E抗腫瘤活性研究(81773586),2018/01-2021/12,55萬元,主持,在研。 2、山東省重點(diǎn)研發(fā)計劃項目,海洋來源靶向抗腫瘤活性溴酚化合物的合成、結(jié)構(gòu)優(yōu)化及成藥性研究(2016GSF201193),2016/01-2017/12,10萬元,主持,已結(jié)題。 3、中國博士后科學(xué)基金特別資助項目,溴酚化合物與吲哚酮雜合體的設(shè)計合成及抗腫瘤活性研究(2015T80755),2015/07-2016/12,15萬元,主持,已結(jié)題。 4、中國博士后科學(xué)基金特別面上項目,海洋溴系化合物LP3的合成、結(jié)構(gòu)修飾及抗腫瘤活性研究(2014M551971),2014/05-2015/08,5萬元,主持,已結(jié)題。 |
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1. Guo, C.-L.#;Wang, L.-J.#,*; Li, X.-X.; Wang, S.Y.; Yu, X.M.; Xu, K.; Zhao, Y.; Luo, J.; Li, X.Q.; Jiang, B.; Shi, D.-Y.*, Discovery of novel bromophenol - thiosemicarbazone hybrids as potent selective inhibitors of Poly(ADP-ribose) polymerase-1 (PARP-1) for use in cancer.Journal of Medicinal Chemistry.2019, 62, 3051-3067. 2. Wang, L.-J.#,*; Guo, C.-L.#; Li, X.-X.; Li, X.Q.; Xu, K.; Jiang, B.; Jia, X.L.; Li, C.; Shi, D.-Y.*Design, synthesis and biological evaluation of bromophenol-thiazolylhydrazone hybrids inhibiting the interaction of translation initiation factors eIF4E/eIF4G as multifunctional agents for cancer treatment.European Journal of Medicinal Chemistry.2019, 177, 153-170. 3. Wang, L.-J.; Geng, C.-A.; Ma, Y.-B.; Luo, J.; Huang, X.-Y.; Chen, H.; Zhou, N.-J.; Zhang, X.-M.; Chen, J.-J.*, Design, synthesis, and molecular hybrids of caudatin and cinnamic acids as novel anti-hepatitis B virus agents.European Journal of Medicinal Chemistry2012,54, 352-365. 4. Li, H.; Guo, C.-L.; Guo, S.J.; Fan, J.-T.;Wang, L.-J.;*Shi, D.-Y.*Design and synthesis of two efficient chalcone-analogue fluorescent probes with 2,4-dinitrophenyl for detecting thiophenols and their application in samples of seawater.Talanta.2019,201,301-308. 5. Guo, C.; Hou, Y.; Yu, X.; Zhang, F.; Wu, X.; Wu, X.*;Wang, L.*, The ERK-MNK-eIF4F signaling pathway mediates TPDHT-induced A549?cell death in vitro and in vivo.Food and chemical toxicology2020,137, 111158. 6. Guo, C.*; Zhang, F.; Wu, X.; Yu, X.; Wu, X.; Shi, D.*;Wang, L.*, BTH-8, a novel poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor, causes DNA double-strand breaks and exhibits anticancer activities in vitro and in vivo.International Journal of Biological Macromolecules2020,150, 238-245. 7. Wang, L.-J.#; Guo, C.-L.#; Li, X.-Q.; Wang, S.-Y.; Jiang, B.; Zhao, Y.; Luo, J.; Xu, K.; Li, H.; Guo, S.J.; Wu, N.; Shi, D.-Y.*, Discovery of Novel Bromophenol Hybrids as Potential Anticancer Agents through the Ros-Mediated Apoptotic Pathway: Design, Synthesis and Biological Evaluation.Marine Drugs2017,15(11), 343-360. 8. Wang, L.-J.#;Wang, S.-Y.#; Jiang, B.; Wu, N.;Li, X.-Q.; Wang, B.-C.; Luo, J.; Yang, M.; Jin, S.-H.; Shi, D.-Y.*, Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents.Marine Drugs2015,13(2), 806-823. 9. Wang, L.-J.; Geng, C.-A.; Ma, Y.-B.; Huang, X.-Y.; Luo, J.; Chen, H.; Guo, R.-H.; Zhang, X.-M.; Chen, J.-J.*, Synthesis, structure-activity relationships and biological evaluation of caudatin derivatives as novel anti-hepatitis B virus agents.Bioorganic & Medicinal Chemistry2012,20(9), 2877-2888. 10. Wang, L.-J.; Geng, C.-A.; Ma, Y.-B.; Huang, X.-Y.; Luo, J.; Chen, H.; Zhang, X.-M.; Chen, J.-J.*, Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.Bioorganic & Medicinal Chemistry Letters2012,22(10), 3473-3479. |
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