理學博士,研究方向為海洋藥物與生物制品,主要聚焦海洋生物活性分子的發(fā)現(xiàn)、結(jié)構(gòu)解析、作用機理與成藥性研究等。在解析海洋中藥海蟑螂鎮(zhèn)痛抗炎物質(zhì)基礎以及發(fā)現(xiàn)降血壓、抗凝血的海洋活性寡肽等方面做出了創(chuàng)新性研究。以第一作者、通訊作者在Int. J. Biol. Macromol.、Food Res. Int.、Chem.-Biol. Interact.等國際期刊發(fā)表SCI論文14篇(Q1區(qū)論文9篇),承擔國家自然科學基金、山東省自然科學基金以及福建省區(qū)域發(fā)展項目、福建省STS項目等省部級項目6項;以第一發(fā)明人申請國家發(fā)明專利5件,已授權(quán)2件;獲得海洋科學技術(shù)獎一等獎1項(排名第4/7)。
2012.09-2017.06 中國科學院大學/中國科學院海洋研究所,海洋化學,博士;
2007.09-2011.07 山東中醫(yī)藥大學,藥學,學士;
2024.12至現(xiàn)在?中國科學院海洋研究所,副研究員;
2019.09-2024.12 中國科學院海洋研究所,助理研究員;
2017.08-2019.08 中國科學院海洋研究所,博士后;
1.?國家自然科學基金青年基金,41906082,2020/01-2022/12,項目負責人;
2.中國博士后科學基金面上項目(一等資助),2018M630805,2018/06-2020/06,項目負責人;
3.?山東省自然科學基金,ZR2019BD025,2019/07-2022/06,項目負責人;
4.?福建省區(qū)域發(fā)展項目,2020N3011,2020/08-2022/12,項目技術(shù)負責人;?
5.福建省STS項目,2023T3034,2023/01-2025/12,項目技術(shù)負責人;
6.?國家自然科學基金面上項目,41776163,2018/01-2021/12,科研骨干;
1. Qishan Suo, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang, and Yang Yue*. 2024. 'Discovery of a novel nanomolar angiotensin-I converting enzyme inhibitory peptide with unusual binding mechanisms derived from Chlorella pyrenoidosa', International Journal of Biological Macromolecules, 280: 135873.
2. Yuhong Ouyang,Yang Yue*, Ning Wu, Jing Wang, Lihua Geng, and Quanbin Zhang*. 2024. 'Identification and anticoagulant mechanisms of novel factor XIa inhibitory peptides by virtual screening of a in silico generated deep-sea peptide database', Food Research International, 197: 115308.
3. Yang Yue, Huahua Yu*, Qishan Suo, Rongfeng Li, Song Liu, Ronge Xing, Quanbin Zhang, Pengcheng Li. Discovery of a novel jellyfish venom metalloproteinase inhibitor from secondary metabolites isolated from jellyfish-derived fungus Aspergillus versicolor SmT07[J]. Chemico-Biological Interactions, 2022, 365: 110113.
4. Qishan Suo, Yang Yue*, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang*. Isolation, identification and in vivo antihypertensive effect of novel angiotensin I-converting enzyme (ACE) inhibitory peptides from Spirulina protein hydrolysate[J]. Food & Function, 2022, 13(17): 9108-9118.
5. Zhenzhen Deng, Jing Wang, Ning Wu, Lihua Geng, Quanbin Zhang, Yang Yue*. Co-activating the AMPK signaling axis by low molecular weight fucoidan LF2 and fucoxanthin improves the HFD-induced metabolic syndrome in mice[J]. Journal of Functional Foods, 2022, 94: 105119.
6. Yang Yue, Huahua Yu*, Rongfeng Li, Pengcheng Li*, 2021. Topical exposure to Nemopilema nomurai venom triggers oedematogenic effects: enzymatic contribution and identification of venom metalloproteinase. Toxins,13(1).
7. Yang Yue, Quanbin Zhang*, Jing Wang, 2019. Integrated gas chromatograph-mass spectrometry (GC/MS) and MS/MS-based molecular networking reveals the analgesic and anti-inflammatory phenotypes of the sea slater Ligia exotica. Marine Drugs,17(7): 395.
8. Yang Yue, Huahua Yu*, Rongfeng Li, Ronge Xing, Song Liu, Pengcheng Li*, 2019. Insights into individual variations in nematocyst venoms from the giant jellyfish Nemopilema nomurai in the Yellow Sea. Scientific Reports, 9(1): 3361.
9. Yang Yue, Huahua Yu*, Rongfeng Li, Ronge Xing, Song Liu, Kecheng Li, Xueqin Wang, Xiaolin Chen, Pengcheng Li*, 2017. Functional elucidation of Nemopilema nomurai and Cyanea nozakii nematocyst venoms’ lytic activity using mass spectrometry and zymography. Toxins, 9, 47; doi:10.3390/toxins9020047.
10. Yang Yue, Huahua Yu* , Rongfeng Li, Ronge Xing, Song Liu, Kecheng Li, Xueqin Wang, Xiaolin Chen, Pengcheng Li*, 2017. Biochemical and kinetic evaluation of the enzymatic toxins from two stinging scyphozoans Nemopilema nomurai and Cyanea nozakii. Toxicon, 125, 1-12.
1.岳洋,?張全斌,?王晶,?耿麗華,?吳寧.?一種海蟑螂低聚物的制備方法及其應用,?專利證書號:?ZL 202210932609.7.?授權(quán)日期:?2023.07.18.
2.岳洋,?張全斌,?王晶,?牛錫珍,?耿麗華.?海蟑螂有機溶劑提取物的應用及組合物,?專利證書號:?ZL 201910221168.8,?授權(quán)日期:?2023.11.24.
3.張全斌, 索齊善, 岳洋, 王晶, 吳寧, 耿麗華. 螺旋藻降壓肽及應用. 專利證書號:ZL202111200168.3. 授權(quán)日期:?2023.07.04.
4.張全斌, 索齊善, 岳洋, 王晶, 吳寧, 耿麗華. 一種降壓肽及其制備方法和應用. 專利證書號:ZL2021111200166.4. 授權(quán)日期:?2023.07.04.
1.海洋科學技術(shù)獎一等獎(2018年,排名4/7)
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